Sodium Acetate BP USP IP ACS AR Analytical Reagent FCC Food Grade Manufacturer Exporter
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Hazard Statements:
Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
This substance is not classified as dangerous according to Directive 67/548/EEC.
Not considered hazardous by the OSHA Hazard Communication Standard (29 CFR 1910.1200)
Signal Word: NoneTransport Information
DOT USA, TDG Canada & ADR/RID Europe: Not dangerous goods.
IMO/IMDG: Not dangerous goods.
IATA/ICAO: Not dangerous goods.You may please visit
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Sodium Acetate IP & Pure Grade Manufacturer
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CAS: 127-09-3 (Sodium Acetate Anhydrous); 6131-90-4 (Sodium Acetate Trihydrate)
Chemical Formula: CH3COO-Na; Molecular Weight: 82Sodium Acetate USP Specifications
Sodium Acetate USP
C2H3NaO2·3H2O 136.08Assay Sodium Acetate contains three molecules of water of hydration, or is anhydrous. It contains not less than 99.0 percent and not more than 101.0 percent of C2H3NaO2, calculated on the dried basis.
Packaging and storage Preserve in tight containers.
Labeling Label it to indicate whether it is the trihydrate or is anhydrous. Where Sodium Acetate is intended for use in hem dialysis, it is so labeled.
Identification A solution responds to the test for Sodium and for Acetate.
pH: between 7.5 and 9.2, in a solution in carbon dioxide-free water containing the equivalent of 30 mg of anhydrous sodium acetate per mL.
Loss on drying Dry at 120 to constant weight: the hydrous form loses between 38.0% and 41.0% of its weight, and the anhydrous form loses not more than 1.0% of its weight.
Insoluble matter Dissolve the equivalent of 20 g of anhydrous sodium acetate in 150 mL of water, heat to boiling, and digest in a covered beaker on a steam bath for 1 hour. Filter through a tarred filtering crucible, wash thoroughly, and dry at 105C: the weight of the residue does not exceed 10 mg (0.05%).
Chloride A portion equivalent to 1.0 g of anhydrous sodium acetate shows no more chloride than corresponds to 0.50 mL of 0.020 N hydrochloric acid (0.035%).
Sulfate A portion equivalent to 10 g of anhydrous sodium acetate shows no more sulfate than corresponds to 0.50 mL of 0.020 N sulfuric acid (0.005%).
Calcium and magnesium To 20 mL of a solution containing the equivalent of 10 mg of anhydrous sodium acetate per mL add 2 mL each of 6 N ammonium hydroxide, ammonium oxalate TS, and dibasic sodium phosphate TS: no turbidity is produced within 5 minutes.
Potassium Dissolve the equivalent of 3 g of anhydrous sodium acetate in 5 mL of water, add 1N acetic acid drop wise until the solution is slightly acidic, and then add 5 drops of sodium cobalt nitrite TS: no precipitate is formed.
Aluminum: (where it is labeled as intended for use in hem dialysis) the limit is 0.2΅ =g per g.
Heavy metalsthe limit is 0.001%.
Organic volatile impurities: meets the requirements.
Sodium Acetate Trihydrate BP Specifications
Sodium Acetate BP
C2H3NaO2,3H2O
Action and use
Used in solutions for dialysis; excipient.DEFINITION
Sodium ethanoate trihydrate.
Content
99.0 per cent to 101.0 per cent (dried substance).CHARACTERS
Appearance
Colourless crystals.
Solubility
Very soluble in water, soluble in ethanol (96 per cent).IDENTIFICATION
A. 1 ml of solution S (see Tests) gives reaction (b) of acetates.
B. 1 ml of solution S gives reaction (a) of sodium.
C. Loss on drying (As shown in the Relevant Test).TESTS
Solution S
Dissolve 10.0 g in carbon dioxide-free water prepared from distilled water R and dilute to 100 ml 100 ml with the same solvent.
Appearance of solution
Solution S is clear and colourless.
pH
7.5 to 9.0.
Dilute 5 ml of solution S to 10 ml with carbon dioxide-free water.
Reducing substances
Dissolve 5.0 g in 50 ml of water, then add 5 ml of dilute sulphuric acid and 0.5 ml of 0.002 M potassium permanganate. The pink colour persists for at least 1 h. Prepare a blank in the same manner but without the substance to be examined.
Chlorides
Maximum 200 ppm.
Sulphates
Maximum 200 ppm.
Aluminium
Maximum 0.2 ppm, if intended for use in the manufacture of dialysis solutions.
Arsenic
Maximum 2 ppm, determined on 0.5 g.
Calcium and magnesium
Maximum 50 ppm, calculated as Ca.
Heavy metals
Maximum 10 ppm.
Iron
Maximum 10 ppm, determined on 10 ml of solution S.
Loss on drying
39.0 per cent to 40.5 per cent, determined on 1.000 g by drying in an oven at 130C.
Sodium Acetate IP Pharma Grade
Dry Basis Assay: 99 to 101%
Characteristics: Colourless Crystals
Solubility: Soluble in 0.8 part of water and in 19 parts of Ethanol (96%)
Clarity and colour of 10% w/v solution: Clear and Colourless
Alkalinity (pH of 5% solution): 7.5-9.0
Arsenic: 2 ppm
Calcium and Magnesium (calculated as Ca): 50 ppm
Heavy Metals as Lead: 10 ppm
Iron: 10 ppm
Chloride: 200 ppm
Sulphate: 200 ppm
Reducing Substances: Passes test
Sodium Acetate FCC US Food Chemical Codex
C2H3NaO2 Formula weight, anhydrous 82.03
C2H3NaO2·3H2O Formula weight, trihydrate 136.08DESCRIPTION
Sodium Acetate occurs as colorless, transparent crystals or as a granular, crystalline or white powder. The anhydrous form is hygroscopic; the trihydrate effloresces in warm, dry air. One gram of the anhydrous form dissolves in about 2 mL of water; 1 g of the trihydrate dissolves in about 0.8 mL of water and in about 19 mL of alcohol.
Function: Buffer.REQUIREMENTS
Identification: A 1:20 aqueous solution gives positive tests for Sodium and for Acetate.
Assay: Not less than 99.0% and not more than 101.0% of C2H3NaO2 after drying.
Alkalinity Anhydrous: Not more than 0.2%; Trihydrate: Not more than 0.05%.
Lead: Not more than 2 mg/kg.
Loss on Drying: Anhydrous: Not more than 1.0%; Trihydrate: Between 36.0% and 41.0%.
Potassium Compounds: Passes test.
Sodium Acetate ACS specifications
American Chemical Society Reagent Grade
Sodium Acetate Anhydrous
CH3COONa
Formula Wt 82.03
CAS Number 127-09-3REQUIREMENTS
Assay: 99.0% C2H3O2Na
pH of a 5% solution: 7.0-9.2 at 25CMAXIMUM ALLOWABLE
Insoluble matter: 0.01%
Loss on drying at 120C: 1.0%
Chloride (Cl): 0.002%
Phosphate (PO4): 0.001%
Sulfate (SO4): 0.003%
Calcium (Ca): 0.005%
Magnesium (Mg): 0.002%
Heavy metals (as Pb): 0.001%
Iron (Fe): 0.001%
Sodium Acetate Trihydrate ACS specifications
American Chemical Society Reagent Grade
NaC2H3O2 . 3H2O
Formula weight 136.08
CAS Number 6131-90-4REQUIREMENTS
Assay: 99.0-101% NaC2H3O2 . 3H2O
pH of a 5% solution: 7.5-9.2 at 25C
Substances reducing permanganate: Passes testMAXIMUM ALLOWABLE
Insoluble matter: 0.005%
Chloride (Cl): 0.001%
Phosphate (PO4): 5 ppm
Sulfate (SO4): 0.002%
Heavy metals (as Pb): 5 ppm
Iron (Fe): 5 ppm
Calcium (Ca): 0.005%
Magnesium (Mg): 0.002%
Potassium (K): 0.005%Contact for Monograph, Uses, Matnfacturing Process, etc of Sodium Acetate Anhydrous Trihydrate and JP IP BP USP ACS AR Analytical reagent FCC Food Grade Manufacturer Supplier Exporter
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